ROLE OF ENZYMATIC ACTIVITY IN MUSCLE DAMAGE AND CYTOTOXICITY INDUCED BY BOTHROPS ASPER ASP49 PHOSPHOLIPASE A2 MYOTOXINS: ARE THERE ADDITIONAL EFFECTOR MECHANISMS INVOLVED?

Viperid venoms often contain mixtures of Asp49 and Lys49 PLA2 myotoxin isoforms, relevant to development of myonecrosis.Given their difference in catalytic activity, mechanistic studies on each type require highly purified samples.Studies on Asp49 PLA2s have shown that enzyme inactivation using p-bromophenacyl bromide (p-BPB) drastically affects to

Obsessive compulsive disorder (OCD) is a common psychiatric disorder which is easily recognized.However, sometimes patients of OCD present in such an atypical or bizarre way that their problem comes to notice as being a psychiatric disorder after multiple consultations in different specialties.We are reporting a case of a man who had first sought o

Selection of genes involved in metabolic pathways could target them differently depending on the position of genes in the pathway and on their role in controlling metabolic fluxes.This hypothesis was tested in the carotenoid biosynthesis pathway using population genetics and phylogenetics.Evolutionary rates of seven genes distributed along the caro

Hydraulic fracturing has become one of the most popular techniques for exploring sustainable energy sources.However, friction is associated with the entire fracturing process, presenting significant challenges for trolley liner development.Facing the huge friction challenges, this review is elaborated in the following three aspects: (1) the fundame